TCC-GUI is a Shiny-based application for differential expression analysis of RNA-Seq count data. It contains all the major functionalities of the TCC R package, including differential expression pipelines with robust normalization and simulation data generation under various conditions. It also contains (i) tools for exploratory analysis, including a useful score termed average silhouette that measures the degree of separation of compared groups, (ii) visualization tools such as volcano plot and heatmap with hierarchical clustering, and (iii) a reporting tool using R Markdown. By virtue of the Shiny-based GUI framework, users can obtain results simply by mouse navigation. Original publication: TCC-GUI: a Shiny-based application for differential expression analysis of RNA-Seq count data Wei Su, Jianqiang Sun, Kentaro Shimizu and Koji Kadota. BMC Research Notes 2019 12:133

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