GPKPDviz: Interactive PK/PD Modeling and Dosing Strategy Explorer
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Last accessed
Jul 02, 2026
About the app
An app developed at Genentech for real-time simulation, visualization, and evaluation of pharmacokinetic/pharmacodynamic (PK/PD) models. Powered by the mrgsolve engine, it supports both virtual and clinical trial populations, enabling users to explore the impact of covariates and dosing regimens—including complex scenarios like loading or intermittent dosing—on PK/PD outcomes. The app allows internal generation or external loading of dosing and sampling schedules, and can perform population or individual simulations using post hoc parameters. A built-in model editor with debugging mirrors mrgsolve's behavior in R, and validation efforts confirm its accuracy against native mrgsolve results. GPKPDviz is part of a suite of modeling tools designed to streamline pharmacometric workflows in clinical pharmacology.
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