DIME, an app for assessing the impact of disease genes on immune cells, employs non-negative matrix factorization to identify clusters of disease-associated cells (DAC) expressing disease-associated genes (DAG). DIME network integrates with DisGeNet network, offering a comprehensive analysis. DIME, standing for Disease-gene IMmune cell Expression network, enables the study of cell-specific disease mechanisms and identifies common DACs and top-weighted DAGs between disease pairs, defining a shared cell-gene network. Additionally, DIME aids in identifying drug repurposing targets and determining top genes and cells associated with diseases from DisGeNet, EBI GWAS, or user-defined gene sets. It explores the cumulative effect of disease-associated genes on immune functions, integrating disease gene networks with transcriptome profiles of 40 immune cells to generate a comprehensive Disease-gene IMmune cell Expression network. Published: Devaprasadet al. Front Immunol. 2021; 12: 669400.

Safety starts with understanding how developers collect and share your data. Data privacy and security practices may vary based on your use, region, and age. The developer provided this information and may update it over time.

No application notes or reviews.